Methylated B-Complex
Active coenzyme B vitamins in a USP vegetable glycerin base, no alcohol, no oil. Built for MTHFR. The same clean carrier trusted by Thorne and Pure Encapsulations, now in a liquid B-complex.
Shop methylated B-complex vitamins
3 productsMETHL’s Liquid B-Complex delivers active coenzyme forms, methylcobalamin, L-5-MTHF, and P-5-P, in a clean USP vegetable glycerin base. No alcohol (ethanol blocks thiamine absorption). No oil (a barrier without benefit for water-soluble B vitamins). The same clean carrier used by Thorne, Pure Encapsulations, and Designs for Health, now with a TMG methyl-donor cofactor, formulated for the 40-60% with an MTHFR variant.
METHL Methylated B Complex Liquid...
Clean methylated B-complex in a USP vegetable glycerin base. No alcohol. No...
METHL'S Methylated Multivitamin and Liquid...
Fuel your body with our Methylated Multivitamin and fast-absorbing Liquid B12+ Complex....
METHL'S Methylated Multivitamin
The METHL Methylated Multivitamin delivers essential vitamins and minerals in their most...
What’s actually inside.
| Nutrient | Form | Per 2 mL |
|---|---|---|
| Thiamine (B1) | Thiamine HCl | 2 mg |
| Riboflavin (B2) | Riboflavin-5-Phosphate (R-5-P) | 2 mg |
| Niacin (B3) | Niacinamide | 20 mg |
| Pantothenic Acid (B5) | Calcium Pantothenate | 10 mg |
| Pyridoxine (B6) | Pyridoxal-5-Phosphate (P-5-P) | 3 mg |
| Biotin (B7) | D-Biotin | 300 mcg |
| Folate (B9) | L-5-MTHF (Methylfolate) | 400 mcg DFE |
| Cobalamin (B12) | Methylcobalamin | 500 mcg |
| TMG (Betaine) | Trimethylglycine | 100 mg |
Serving: 2 mL (2 full droppers). Other ingredients: USP vegetable glycerin, purified water.
Why USP vegetable glycerin, not alcohol or oil
Alcohol tinctures use ethanol as a preservative, but ethanol blocks thiamine (B1) by downregulating the intestinal thiamine transporter THTR-1, and acetaldehyde degrades pyridoxine (B6). Oil-based liposomal carriers encapsulate water-soluble B vitamins in a phospholipid shell, adding a barrier without meaningful benefit. METHL uses USP vegetable glycerin and purified water, the same clean carrier used in practitioner-grade liquids by Thorne, Pure Encapsulations, and Designs for Health.
Coenzyme forms, no conversion.
Methylcobalamin B12
The active coenzyme form of B12. Cyanocobalamin must be converted in two steps; methylcobalamin is used directly for methylation, nerve repair and red blood cell production.
L-5-MTHF (Methylfolate)
The active folate your cells use directly. Folic acid requires the MTHFR enzyme to convert; 40-60% of people carry a variant that limits this step. 5-MTHF bypasses it entirely.
TMG Methyl-Donor Cofactor
Trimethylglycine donates methyl groups to support the methylation cycle, working alongside methylcobalamin and methylfolate to keep homocysteine in healthy range.
R-5-P (Active B2) & P-5-P (Active B6)
Riboflavin-5-Phosphate and Pyridoxal-5-Phosphate are the coenzyme forms of B2 and B6 your mitochondria use directly for energy metabolism, no conversion step.
Methylated B-complex vitamins, explained.
A methylated B-complex delivers B vitamins in their active coenzyme forms, the versions your cells use directly without a conversion step. Most B-complex supplements use cyanocobalamin for B12 and folic acid for B9. Your body has to convert both before they are usable, a two-step process for B12 and an MTHFR-enzyme-dependent step for folate. METHL skips those steps: B12 as methylcobalamin and B9 as L-5-MTHF (methylfolate).
Why methylated B vitamins. An estimated 40-60% of people carry an MTHFR gene variant that limits the conversion of folic acid to usable methylfolate. For this group, a standard B-complex delivers the precursor but the body cannot fully process it. Methylated forms are bioavailable whether or not you carry the variant, a smart default for everyone.
Methylcobalamin vs cyanocobalamin. Cyanocobalamin is a cheap synthetic form of B12 that must be converted in two enzymatic steps before use. Methylcobalamin is the active coenzyme form: it participates directly in methylation reactions and myelin synthesis, no conversion required, and no cyanide group to clear.
Why glycerin instead of alcohol or oil. Most liquid B-complex products use an ethanol base. Ethanol downregulates THTR-1, the intestinal transporter for thiamine (B1), directly undermining one of the nutrients being delivered. Oil-based liposomal carriers were designed for fat-soluble compounds and add a barrier without benefit for water-soluble B vitamins. METHL uses a USP vegetable glycerin and purified water base, the same carrier used by Thorne, Pure Encapsulations, and Designs for Health.
What is TMG. Trimethylglycine (betaine) is a methyl-donor compound that donates methyl groups directly to the methylation cycle. When methylcobalamin and methylfolate support the methionine pathway, TMG acts as an independent backup methyl donor, helping maintain healthy homocysteine levels through the BHMT enzyme pathway. METHL includes 100 mg TMG per 2 mL serving as a cofactor alongside the full active B stack.
Which METHL is right for you? Start with the Liquid B-Complex Drops for targeted energy, mood and methylation support via active B vitamins. Add the Methylated Multivitamin for a full-spectrum daily foundation with 19 vitamins and minerals plus fermented organic greens. The Bundle pairs both at the best value. Every formula is made in the USA, third-party tested, vegan and non-GMO, with no synthetic fillers, backed by a 60-day money-back guarantee.
The problem isn’t you. It’s the form of your B vitamins.
Most B-complex supplements use synthetic forms your body has to convert before it can use them. If that conversion runs slow, you can take a B vitamin every day and still feel the gap. Here’s what that looks like, and what METHL does differently.
You sleep enough but still drag
B vitamins are the fuel converters behind every cell’s energy production. When they arrive as inactive precursors your cells have to process first, the conversion bottleneck means the tank never quite fills.
METHL uses methylcobalamin B12 and active coenzyme B vitamins your cells use immediately, no extra conversion step required.
Words and focus slip by mid-morning
Methylation builds the neurotransmitters behind focus, mood and mental clarity. When folate and B12 arrive in synthetic form and the conversion pathway runs slow, neurotransmitter production runs short.
METHL delivers L-5-MTHF and methylcobalamin, the active forms that feed methylation directly without waiting on a conversion step.
You convert folic acid poorly
An estimated 40 to 60 percent of people carry an MTHFR variant that limits the conversion of folic acid to usable methylfolate. Standard B-complex formulas deliver the precursor, but the enzyme can’t fully process it.
METHL skips the bottleneck entirely with pre-activated L-5-MTHF folate. See the MTHFR guide.
Your B12 still has a conversion job to do
Cyanocobalamin is a cheap, synthetic B12 that requires two enzymatic steps before your body can use it, and it carries a cyanide group your liver must clear. It works for many people, but it is not the most direct route.
METHL uses methylcobalamin exclusively, the active coenzyme form that participates in methylation reactions without any conversion. See the difference.
Your formula lists synthetic folic acid
Unconverted folic acid can accumulate in the bloodstream. It is inexpensive to manufacture, which is why most B-complex products still use it. For people with MTHFR variants, the conversion may stall significantly.
METHL contains no synthetic folic acid, only natural L-5-MTHF. See the science.
You take B vitamins and still feel the same
If you have been taking a standard B-complex for months with little change, the formula form is often the variable. Inactive precursors depend on your enzymatic capacity to deliver the end result.
METHL delivers coenzyme forms your cells recognize on contact, bypassing the conversion steps that can blunt results from conventional formulas.
Your liquid B drops use ethanol
Ethanol-based tinctures are common in liquid supplements, but ethanol downregulates THTR-1, the intestinal transporter for thiamine (B1), directly reducing absorption of one of the nutrients being delivered.
METHL uses a clean USP vegetable-glycerin and purified-water base, the same carrier used by Thorne, Pure Encapsulations and Designs for Health.
You feel flat, wired or on edge
Your body uses methylation to build serotonin, dopamine and other mood-regulating compounds. Weak B-vitamin status, especially folate and B12, can leave that supply short over time.
METHL delivers L-5-MTHF, methylcobalamin, P5P (active B6) and TMG, the active stack behind neurotransmitter production and the methylation cycle.
You want to keep homocysteine in range
Folate, B12 and B6 work together to manage homocysteine levels. In inactive precursor form, they may not perform that job as efficiently, particularly if conversion capacity is limited.
METHL provides all three as active methylated forms, plus TMG as an independent methyl donor through the BHMT pathway, for comprehensive homocysteine support.
Find your METHL.
One question, we’ll match you to the right formula.
Liquid B-Complex Drops
Fast-absorbing methylated B-complex with methylcobalamin, L-5-MTHF and TMG in a clean USP glycerin base. Two droppers a day for steady energy, mood and MTHFR support.
Multivitamin + B-Complex Bundle
The complete system: the daily multivitamin foundation plus the liquid B-complex for full-spectrum methylation coverage, at the best price.
Methylated Multivitamin
Your everyday baseline: 19 active vitamins and minerals plus fermented organic greens in one daily capsule. Built for MTHFR, absorbable for everyone.
METHL vs the B-complex you have now.
| What matters | Standard B-complex | METHL Liquid B-Complex |
|---|---|---|
| Methylcobalamin (active B12) | ✕ Cyanocobalamin | ✓ |
| L-5-MTHF (active folate) | ✕ Folic acid | ✓ |
| Works with MTHFR variant | ✕ | ✓ |
| USP glycerin base (no alcohol) | ✕ Ethanol | ✓ |
| TMG methyl-donor cofactor | ✕ | ✓ |
| Active B2 (R-5-P) & B6 (P-5-P) | Rarely | ✓ |
| Third-party tested | Rarely | ✓ |
| No synthetic fillers | Common | ✓ |
“The glycerin-based delivery for a methylated B-complex is the right call. Ethanol tinctures compromise B1 absorption by downregulating THTR-1. METHL’s choice of active coenzyme forms, particularly methylcobalamin, L-5-MTHF, and P-5-P, with TMG as a cofactor, reflects a real understanding of how the methylation cycle works in practice.”
People who finally feel it.
“Absolutely the best vitamins I have ever taken. These vitamins are absolutely the best.”
“My doctor gave me a list of recommended vitamins for my neuropathy. Your product was recommended because it provides more of the vitamins than other products. Makes my daily routine easier.”
“Well tolerated!”
“I looked at every B-complex on the market. Most had cyanocobalamin, folic acid, and an alcohol base. I wanted methylcobalamin, L-5-MTHF, and a clean glycerin carrier that wouldn’t interfere with the very nutrients it was supposed to deliver. That’s what METHL is.”
60-day money-back guarantee.
We’re confident you’ll feel the difference. If you’re not completely satisfied, return it within 60 days for a full refund. No questions asked.
Try for 60 days
Take METHL Liquid B-Complex daily to experience the difference.
Contact us
Not satisfied? Reach out for return instructions.
Get a full refund
Return it and we’ll process your refund promptly.
Active coenzyme forms
Methylcobalamin, L-5-MTHF, P-5-P, R-5-P: the exact forms your cells use directly, no intermediate conversion step required.
Clean glycerin carrier
USP vegetable glycerin preserves B vitamins without ethanol, the same base used by Thorne and Pure Encapsulations.
Built for MTHFR
40-60% of people can’t efficiently convert cyanocobalamin or folic acid. METHL starts with the active forms, bioavailable for everyone.
Why you can trust METHL
The methylated B-complex FAQ.
What is a methylated multivitamin? +
It delivers folate and B12 in their active forms (5-MTHF and methylcobalamin), so your body doesn’t have to convert them first. Read our full guide to what a methylated multivitamin is.
Who should not take methylated B vitamins? +
Most people do well on them. If you’re sensitive to B vitamins or feel overstimulated, start low. If you take medication or have a health condition, check with your clinician first.
How do I know if I need methylated B vitamins? +
You don’t need a test. Ongoing fatigue or brain fog on a standard B-complex can be a hint, especially for vegans, older adults, and the many people who convert synthetic B vitamins slowly.
Is there a difference between B12 and methylated B12? +
Yes. Methylated B12 (methylcobalamin) is the active form your body uses directly, while synthetic B12 (cyanocobalamin) must be converted first.
Can methylated B vitamins cause anxiety? +
A small number of people feel ‘wired’ if they take more than they need. Starting at the labeled dose and taking it in the morning usually prevents that. If it persists, talk with your clinician.
Is it third-party tested? +
Yes. Every batch is third-party tested for purity and potency, so what’s on the label is what’s in the bottle. We believe verification should be the standard, not a marketing line.
Can I take it every day? +
Yes, it’s built as a daily foundation. The water-soluble vitamins aren’t stored, so any excess is simply excreted. Start at the labeled dose and take it with food for the best absorption.
Can I take it if I’m pregnant or breastfeeding? +
Nutrient needs change during pregnancy and breastfeeding, so this isn’t a substitute for a prenatal your provider recommends. Talk with your clinician about the right formula and dose for you before starting.
Can I take it with my medications or other supplements? +
Most people can, but some nutrients can interact with certain medications. If you take prescription medication or have a health condition, check with your clinician or pharmacist first.
Get 15% off your first order.
Plus the occasional note on methylation, MTHFR and feeling like yourself again.
Keep Exploring
