Methylated B-Complex

A methylated B-complex delivers B vitamins in their active coenzyme forms, methylcobalamin for B12 and L-5-MTHF for folate, plus coenzyme forms of B2 (R-5-P) and B6 (P-5-P). These are the versions your cells use directly, with no conversion step. Most standard B-complex supplements use cheaper synthetic precursors, cyanocobalamin and folic acid, that your body must convert before use. METHL skips that step.

Methylated B vitamins are bioavailable regardless of your genetics. An estimated 40-60% of people carry an MTHFR gene variant that limits how efficiently they convert folic acid to usable methylfolate. For this group, a standard B-complex delivers the precursor but the body can’t fully process it. Methylated forms work for everyone, MTHFR or not, making them a smarter default for anyone who wants the B vitamins to actually arrive.

Cyanocobalamin is a cheap synthetic form of B12 that must be converted in two enzymatic steps before your body can use it. It also contains a cyanide group your body must clear. Methylcobalamin is the active coenzyme form of B12: it participates directly in methylation reactions and myelin synthesis with no conversion required. METHL uses methylcobalamin exclusively.

Ethanol tinctures are common in liquid supplements, but ethanol downregulates THTR-1, the intestinal thiamine transporter, directly reducing B1 absorption. Acetaldehyde from ethanol also degrades pyridoxine (B6). Oil-based liposomal carriers were engineered for fat-soluble nutrients and add a phospholipid barrier without meaningful benefit for water-soluble B vitamins. METHL uses USP vegetable glycerin and purified water, the same clean carrier used by Thorne, Pure Encapsulations, and Designs for Health.

TMG (Trimethylglycine, or betaine) is a methyl-donor compound that supports the methylation cycle through the BHMT enzyme pathway, independent of the folate-B12 pathway. When methylcobalamin and methylfolate support the methionine cycle, TMG provides an additional methyl-donation route and helps maintain healthy homocysteine levels. METHL includes 100 mg TMG per 2 mL serving as a cofactor alongside the full active B stack.

Shake well, then take 2 full droppers (2 mL) daily. You can take it straight, hold it under your tongue for a few seconds for sublingual absorption, or add it to water or juice. Morning with or without food works well; B vitamins support energy production so most people prefer them earlier in the day.

Yes. They’re designed to work together, which is exactly what the Bundle is. The multivitamin covers your daily foundation with 19 active vitamins, minerals and fermented organic greens, while the liquid B-Complex adds a concentrated, fast-absorbing active B vitamin dose for energy, mood and methylation support.

Most people notice steadier energy and clearer mood within 30 days of daily use, as consistent levels of the active B vitamins accumulate. Because these are coenzyme forms with no conversion step, they are available to your cells faster than standard precursor forms.

Yes. Every batch is independently tested for purity and potency. METHL is vegan, non-GMO, and made in the USA with no synthetic fillers or binders. The ingredient panel lists exactly what is in each 2 mL serving.

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