The Methylated Multivitamin Born From an MTHFR Gene Mutation

MTHFR is a common genetic variation that affects up to 40% of the population. It impairs your body’s ability to convert folic acid and certain B vitamins into their active, usable forms. If you have this variant, standard multivitamins may pass through your body without being absorbed. METHL uses pre-activated, methylated forms that bypass this conversion entirely.

Most multivitamins use cheap, synthetic forms of nutrients that require your body to convert them before use. METHL uses methylated, active-form ingredients, like methylfolate instead of folic acid and methylcobalamin instead of cyanocobalamin, so your body can use them immediately. We’re also free from fillers, binders, and artificial additives, with every batch third-party tested.

No. While METHL was specifically designed with MTHFR carriers in mind, methylated vitamins are more bioavailable for everyone. Even without the mutation, your body absorbs active-form nutrients more efficiently than synthetic alternatives.

All METHL products are formulated and manufactured in the USA in partnership with licensed compounding pharmacies. We source premium raw ingredients globally and every batch undergoes third-party testing for purity, potency, and bioavailability.

METHL formulas feature methylfolate (5-MTHF), methylcobalamin (active B12), organic turmeric, and fermented greens. Every ingredient is vegan, gluten-free, non-GMO, and serves a specific functional purpose. No filler ingredients, ever.

METHL is formulated with clean, bioavailable ingredients that are generally well-tolerated. As with any supplement, we recommend consulting your healthcare provider before combining with other supplements or medications.

Methylated vitamins are nutrients already converted into their active, bioavailable form. Unlike standard synthetic vitamins (like folic acid or cyanocobalamin), they don’t require your body to perform a conversion step before use. This is critical for the estimated 40% of people with MTHFR gene mutations who can’t efficiently make that conversion. Key examples include methylfolate (active folate), methylcobalamin (active B12), and pyridoxal-5-phosphate (active B6). Learn more about methylated vitamins →

For many people, yes. Methylated vitamins are already in their active form, meaning your body can absorb and use them immediately without conversion. This is especially important for the 40% of the population with MTHFR gene mutations, but even people without the variant benefit from higher bioavailability. Studies show methylfolate is more effective at raising folate levels than folic acid. Similarly, methylcobalamin (methylated B12) is better retained by the body than cyanocobalamin. See how methylated B vitamins compare →

The METHL Methylated Multivitamin ($51.99) provides nutrients in their most bioavailable form for maximum absorption. It features 5-MTHF (methylfolate), methylcobalamin (methylated B12), a potent immunity blend, and fermented organic greens. Benefits include better folate and B12 utilization, support for healthy methylation cycles, improved energy metabolism, and no risk of unmetabolized folic acid buildup. Pharmacy-grade, plant-based, vegan, non-GMO, and made in the USA.