Metabolism & Energy Support
B vitamins are cofactors in every energy-production pathway. METHL delivers them in the forms your cells actually use—methylcobalamin B12, active 5-MTHF folate, P5P B6—so your metabolism has what it needs to turn food into fuel.
Shop B vitamins & metabolism support
3 productsB vitamins are required cofactors in the pathways that convert carbohydrates, fats, and protein into ATP—the energy your cells run on. METHL delivers them as methylcobalamin B12, active 5-MTHF folate, and P5P B6, the forms your metabolism can use on contact. Shop the B-vitamin line below.
METHL'S Methylated Multivitamin
The METHL Methylated Multivitamin delivers essential vitamins and minerals in their most...
METHL Methylated B Complex Liquid...
Clean methylated B-complex in a USP vegetable glycerin base. No alcohol. No...
METHL'S Methylated Multivitamin and Liquid...
Fuel your body with our Methylated Multivitamin and fast-absorbing Liquid B12+ Complex....
B vitamins and energy metabolism, explained.
B vitamins and energy metabolism. Every cell in your body produces energy through a series of enzymatic reactions—the citric acid cycle and oxidative phosphorylation—that require B vitamins as coenzymes. B12 (methylcobalamin), folate (5-MTHF), and B6 (P5P) are all active participants in these pathways, not bystanders. Without adequate B vitamins, the pathways that convert carbohydrates, fats, and protein into ATP run at reduced capacity.
Active vs synthetic forms. Standard supplements use synthetic precursors like cyanocobalamin (B12) and folic acid (folate) that your body must convert to active coenzyme forms before your metabolism can use them. METHL delivers methylcobalamin, 5-MTHF, and P5P—the active coenzyme forms—directly. No conversion step, no bottleneck.
The MTHFR connection. An estimated 40–60% of people carry an MTHFR gene variant that limits conversion of synthetic folic acid to usable folate. That same pathway affects how efficiently your body runs methylation reactions linked to energy production. Active forms bypass this entirely, a smart default for everyone.
Which METHL supports metabolism best? The Liquid B-Complex Drops deliver concentrated methylcobalamin B12, 5-MTHF and P5P in a fast-absorbing liquid base—the highest B-vitamin density in the line. Pair it with the Methylated Multivitamin for full-spectrum daily coverage, or grab the Bundle for both at the best value. Also looking for energy support? See our vitamins for energy collection. Every formula is made in the USA, third-party tested, vegan and non-GMO, backed by a 60-day guarantee.
The problem isn’t you. It’s the form of your vitamins.
Most multivitamins are built on synthetic precursors your body has to convert before it can use them. If that conversion runs slow, you can take a vitamin every day and still run low. Here’s what that feels like, and what METHL does about it.
You sleep enough but still drag
B vitamins turn food into usable energy. When they arrive as inactive forms your cells can’t use, the tank never really fills.
METHL uses methylcobalamin B12 and active B vitamins your cells use on contact, no conversion step in between.
Words and focus slip mid-afternoon
Methylation helps build the neurotransmitters behind focus and mood. Weak conversion of folate and B12 can leave that process short.
METHL delivers 5-MTHF folate and methylcobalamin, the forms that feed methylation directly.
You convert folic acid poorly
Roughly a third to half of people carry an MTHFR variant that slows the switch from folic acid to usable folate, so standard multis underdeliver.
METHL is built for MTHFR: it skips the conversion entirely with pre-activated folate. See the MTHFR guide.
Your label lists “folic acid”
Unconverted folic acid can build up in the blood. It’s cheap to manufacture, which is why most multivitamins still use it.
METHL uses no synthetic folic acid, only natural 5-MTHF. See the difference.
You take pills that pass right through
Cheap binders, fillers and hard tablets can limit how much actually reaches your bloodstream.
METHL is a clean vegan formula with no synthetic fillers, plus a fast-absorbing liquid B-Complex option.
You can’t tell what’s really inside
Supplement quality varies widely, and most brands never show third-party proof.
Every METHL batch is third-party tested for purity and potency, vegan, non-GMO, made in the USA.
You feel flat, wired, or on edge
Your body uses methylation to build serotonin, dopamine and other mood chemicals. Weak B-vitamin status can leave that supply short.
METHL delivers 5-MTHF, methylcobalamin and P5P (B6), the active forms behind neurotransmitter production.
You want to support healthy homocysteine
Folate, B12 and B6 work together to keep homocysteine in a healthy range. In inactive forms, they can’t do that job as well.
METHL provides all three as active, methylated forms your body can put to work directly.
You catch whatever’s going around
Daily nutrient gaps can leave your defenses under-supported, especially through busy or high-stress stretches.
The Methylated Multivitamin adds an immunity blend: vitamin C from organic cherry and amla, plus zinc and selenium.
Your diet leaves real gaps, especially B12
Vegan and vegetarian diets are often low in B12 and a few other nutrients that are hard to get from plants alone.
METHL is fully vegan and plant-derived, with B12 as methylcobalamin in a form your body absorbs.
Your supplement shelf is out of control
Juggling five or six bottles is easy to start and hard to keep up. Most days something gets skipped.
METHL pulls your daily foundation, greens and immunity into one clean capsule, with the Bundle if you want B-Complex too.
Pills upset your stomach or are hard to swallow
Hard tablets, fillers and binders can sit heavily, so you stop taking them.
METHL skips synthetic fillers, and the fast-absorbing Liquid B-Complex is an easy no-pill option.
Find your METHL.
One question, we’ll match you to the right formula.

Methylated Multivitamin
Your everyday baseline, 19 active vitamins & minerals plus fermented organic greens, in one daily capsule. Built for MTHFR, absorbable for everyone.

Liquid B-Complex Drops
Fast-absorbing, methylated B-complex with methylcobalamin & TMG in a clean glycerin base, for steady energy, mood and MTHFR support. Just drops a day.

Multivitamin + B-Complex Bundle
The complete system, the daily multivitamin and the liquid B-complex together for full-spectrum methylation coverage, at the best price.
Active B vitamins vs. standard multivitamins.
| What matters | Generic multi | METHL |
|---|---|---|
| Methylated, active B vitamins | ✕ | ✓ |
| Works with an MTHFR variant | ✕ | ✓ |
| Synthetic folic acid | Yes | Never |
| Fermented organic greens | ✕ | ✓ |
| Fillers & binders | Common | None |
| Glass bottle | ✕ | ✓ |
| Third-party tested | Rarely | ✓ |
“B vitamins are essential cofactors in the citric acid cycle and oxidative phosphorylation—the pathways that generate ATP from food. Methylcobalamin and active folate support these reactions directly. METHL delivers them in the forms your metabolism actually uses.”
People who finally feel it.
“Absolutely the best vitamins I have ever taken. These vitamins are absolutely the best.”
“My doctor gave me a list of recommended vitamins for my neuropathy. Your product was recommended because it provides more of the vitamins than other products. Makes my daily routine easier.”
“Well tolerated!”
“I optimized everything and still felt off. Twenty years chasing performance, triathlete, marathon runner, martial artist, and I still couldn’t feel the difference. A genetic test explained why: an MTHFR variant meant my body couldn’t use standard vitamins. So I built the one that didn’t exist on the shelf.”
60-day money-back guarantee.
We’re confident you’ll feel the difference. If you’re not completely satisfied, return it within 60 days for a full refund. No questions asked.
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Take METHL daily to experience the difference.
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Active forms only
5-MTHF folate, methylcobalamin, P5P, the coenzyme forms your body uses directly, no conversion required.
Built for MTHFR
40-60% of people can’t convert synthetic folic acid. METHL skips the step, bioavailable for everyone.
Clean & tested
Made in the USA, third-party tested, vegan, no fillers. Real ingredients, real results.
The metabolism & B-vitamin FAQ.
How do B vitamins support metabolism? +
B vitamins act as coenzymes in the metabolic pathways that convert the food you eat into ATP—the energy currency your cells use. B12 (as methylcobalamin), folate (as 5-MTHF), and B6 (as P5P) are all required for the citric acid cycle and related reactions. Without adequate B vitamins in their active forms, those pathways run at reduced capacity.
Does B12 help with energy metabolism? +
Yes. B12 is a cofactor in multiple enzymatic reactions involved in energy metabolism, including the conversion of methylmalonyl-CoA to succinyl-CoA, a step in the citric acid cycle. It also supports the methylation reactions needed to build and maintain the cells your body uses to produce and deliver energy. METHL uses methylcobalamin, the active form your body uses directly, rather than cyanocobalamin, which requires a conversion step.
What is the role of methylated B vitamins in metabolism? +
Methylated B vitamins—methylcobalamin B12, 5-MTHF folate, and P5P B6—are the coenzyme forms your cells use without any conversion step. Standard supplements often use synthetic precursors like cyanocobalamin and folic acid that must be converted before your metabolism can use them. METHL skips that step, delivering B vitamins in the forms already active in your metabolic pathways.
Will this help my energy? +
If your energy is affected by low or poorly absorbed B vitamins, getting adequate active B vitamins can support normal energy metabolism. METHL is not a stimulant and makes no claim to boost energy; it provides the B-vitamin cofactors your metabolism needs to function as it should. Most people notice steadier, more consistent energy within about 30 days of daily use.
How do I take the Methylated Multivitamin? +
Take your daily serving once a day, ideally with a meal so the fat-soluble nutrients absorb well. Follow the serving size printed on your bottle.
How do I take the Liquid B-Complex? +
Shake well, then take 2 full droppers (2 mL) daily. You can take it straight, hold it under your tongue for a few seconds, or add it to water or juice.
Can I take the Multivitamin and Liquid B-Complex together? +
Yes. They’re designed to work together, which is exactly what the Bundle is. The multivitamin covers your daily foundation while the liquid adds concentrated, fast-absorbing active B vitamins.
What’s the difference between the capsule multivitamin and the liquid B-Complex? +
The Methylated Multivitamin is a complete daily foundation with vitamins, minerals, fermented organic greens and an immunity blend in a vegan capsule. The Liquid B-Complex is a focused dose of active B vitamins in a fast-absorbing liquid for energy, mood and methylation support.
Should I take methylated vitamins with food or on an empty stomach? +
Take the multivitamin capsule with food for the best absorption and the easiest-on-the-stomach experience. The Liquid B-Complex works with or without food.
What time of day should I take B vitamins? +
Morning is ideal. B vitamins support energy production, so most people prefer them earlier in the day rather than right before bed.
How long does one bottle of Liquid B-Complex last? +
About a month. Each 2 fl oz bottle holds roughly 30 daily servings at the 2 mL dose.
Can I take more than the recommended dose? +
Stick to the label. With B vitamins, more is not better, and there’s no benefit to doubling up. If you have questions about dosing for your situation, ask your healthcare provider.
What if I miss a day? +
Just take your next dose as usual. Methylated vitamins work best with steady daily use, so consistency matters more than any single day.
Can I take METHL every day, long term? +
Yes. METHL is built for daily use. You don’t need to cycle off it.
What form of folate does METHL use? +
5-MTHF (L-methylfolate), the active, body-ready form of folate, never synthetic folic acid. Read the full 5-MTHF guide.
What form of B12 is in METHL? +
Methylcobalamin, the active form of B12, rather than cheaper synthetic cyanocobalamin.
What form of B6 does METHL use? +
P5P (pyridoxal-5-phosphate), the active coenzyme form of vitamin B6 your body can use directly.
Does METHL contain synthetic folic acid? +
No. METHL never uses synthetic folic acid. You get natural 5-MTHF instead, which is especially important if you have an MTHFR variant. Here’s why that matters.
Does the Multivitamin contain greens? +
Yes. It includes a fermented organic greens blend alongside the methylated vitamins, minerals and an immunity blend with vitamin C from organic cherry and amla berry, plus zinc and selenium.
Who should take a methylated multivitamin? +
Anyone who wants reliably absorbable nutrients. Active forms benefit everyone, and they’re particularly useful if you have an MTHFR variant, eat a limited diet, or feel low on energy despite taking a standard multi.
Can both men and women take METHL? +
Yes. METHL is formulated for adults of any gender who want active, methylated nutrition.
Is METHL vegan? +
Yes. Both the Methylated Multivitamin and the Liquid B-Complex are vegan and plant-derived, including the capsule.
Is METHL gluten-free? +
Yes. METHL is gluten-free and non-GMO, with no synthetic fillers.
Is the Liquid B-Complex soy-free? +
Yes. The Liquid B-Complex is soy-free, sugar-free, alcohol-free and oil-free, with no synthetic preservatives.
Does METHL contain dairy or animal products? +
No. METHL is fully plant-derived and vegan, so there are no dairy or animal ingredients.
Is there sugar in the Liquid B-Complex? +
No added sugar. It’s naturally sweet on its own, with no sugar, alcohol or synthetic sweeteners.
Why is the liquid naturally sweet if it has no sugar? +
The pleasant taste comes from the plant-derived, self-preserving formula itself, not from added sugar or artificial sweeteners.
Where is METHL made? +
METHL is made in the USA and every batch is third-party tested for purity and potency.
How should I store my methylated vitamins? +
Keep them in a cool, dry place away from direct light and heat. Always reseal the cap, and follow any storage note on your label.
Do I need to shake the Liquid B-Complex? +
Yes. Shake well before each use so the active nutrients are evenly distributed in every dropper.
Will methylated B vitamins turn my urine bright yellow? +
It can, and that’s harmless. The bright color comes from riboflavin (B2) and simply means your body is passing what it doesn’t need that day.
Can I take METHL with my medications or other supplements? +
Usually yes, but always check with your healthcare provider first if you take prescription medication or other supplements, so they can confirm it fits your routine.
Can I take METHL if I’m pregnant or breastfeeding? +
Talk to your OB or healthcare provider before starting any supplement during pregnancy or breastfeeding. Many clinicians favor the active 5-MTHF form of folate, but your provider should guide what’s right for you.
How is METHL different from the multivitamin I have now? +
Most multivitamins rely on synthetic precursors like folic acid and cyanocobalamin that your body must convert. METHL delivers the active forms directly, in a clean vegan formula with greens and an immunity blend, third-party tested and made in the USA.
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Plus the occasional note on B vitamins, metabolism and getting more from what you already eat.
