MTHFR Supplements
40-60% of people carry an MTHFR variant that blocks the conversion of folic acid. METHL skips the conversion entirely, delivering 5-MTHF folate and methylcobalamin your cells can use the moment you take them.
Shop MTHFR supplements
3 productsMETHL provides active methylated forms, 5-MTHF folate and methylcobalamin B12, that bypass the MTHFR enzyme bottleneck entirely. No conversion step, no folic acid accumulation. Designed for people with MTHFR C677T or A1298C variants and more bioavailable for everyone else.
METHL'S Methylated Multivitamin
The METHL Methylated Multivitamin delivers essential vitamins and minerals in their most absorbable, methylated...
METHL Methylated B Complex Liquid Drops...
Clean methylated B-complex in a USP vegetable glycerin base. No alcohol. No oil. No...
METHL'S Methylated Multivitamin and Liquid B...
Fuel your body with our Methylated Multivitamin and fast-absorbing Liquid B12+ Complex. This bundle...
MTHFR: why folic acid is not enough for 40-60% of people.
The MTHFR gene encodes an enzyme that converts folic acid into the active folate your body runs on. When MTHFR activity is reduced, folic acid sits unused and unmetabolized folate may accumulate, while your cells get less of what they actually need.
METHL uses 5-MTHF (L-methylfolate) and methylcobalamin, the pre-activated forms that enter the methylation cycle directly. No MTHFR enzyme required.
MTHFR C677T vs A1298C: what changes and what stays the same.
There are two primary MTHFR variants. Both reduce enzyme activity to different degrees. METHL formulas provide pre-activated folate that bypasses both.
The thermolabile variant
C677T produces an enzyme that is heat-sensitive and less stable. Homozygous carriers (TT genotype) may have MTHFR activity reduced by up to 70%. Heterozygous (CT) carriers see a milder reduction of around 35%.
The regulatory variant
A1298C affects a regulatory domain of the MTHFR enzyme. Homozygous carriers (CC genotype) may have activity reduced by 40%. Compound heterozygous (carrying one C677T and one A1298C) can see a larger combined reduction.
METHL vs generic supplements for MTHFR.
| What matters for MTHFR | Generic supplement | METHL |
|---|---|---|
| Folate as 5-MTHF (active form) | ✕ | ✓ |
| Methylcobalamin B12 (not cyanocobalamin) | ✕ | ✓ |
| Zero synthetic folic acid | Rarely | Always |
| Works without MTHFR conversion | ✕ | ✓ |
| P5P (active B6) | ✕ | ✓ |
| Third-party tested purity | Rarely | ✓ |
| No fillers or binders | Common | None |
Find the right MTHFR supplement for you.
Answer one question and we match you to the best formula for your situation.
Methylated Multivitamin
19 active vitamins and minerals, 5-MTHF folate, methylcobalamin B12, P5P B6, plus fermented organic greens in one daily capsule. Built specifically so MTHFR variants are never a bottleneck.
Liquid B-Complex Drops
Concentrated methylcobalamin, 5-MTHF and TMG (betaine) in a clean vegetable glycerin base. Fast-absorbing liquid format for energy, mood and MTHFR-specific methylation support. Just 2 droppers daily.
Multivitamin + B-Complex Bundle
The complete MTHFR stack. The capsule multivitamin covers your full daily foundation while the liquid B-complex adds concentrated, fast-absorbing active Bs. Everything your methylation cycle needs.
“For anyone with an MTHFR variant, the form of folate in your supplement is not a minor detail, it determines whether you absorb it at all. 5-MTHF bypasses the conversion step that MTHFR polymorphisms impair. Paired with methylcobalamin, this is the most clinically sound approach to supporting methylation.”
People who finally feel it.
“I have the MTHFR C677T mutation and have tried many supplements. These are absolutely the best I have ever taken. I actually feel the difference.”
“My doctor specifically recommended a methylated B12 for my neuropathy. Your product was on the list because it provides the active forms rather than synthetic ones. Makes my daily routine so much easier.”
“Well tolerated and I can tell my body is absorbing it. I have compound heterozygous MTHFR and this is the first supplement that hasn’t upset my stomach at all.”
“A genetic test explained it. An MTHFR variant meant my body couldn’t use the vitamins I was taking. Twenty years of optimization, triathlete, marathon runner, martial artist, still feeling off. The answer was in the form of the nutrient, not the dose. So I built the supplement that skipped the conversion I couldn’t make.”
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MTHFR supplements: what the gene variant means and what to look for.
What is the MTHFR gene? MTHFR (methylenetetrahydrofolate reductase) is a gene that encodes the enzyme responsible for converting dietary folate and synthetic folic acid into 5-MTHF (L-methylfolate), the active form your body uses in the methylation cycle. Methylation governs dozens of biochemical processes including DNA synthesis, neurotransmitter production, homocysteine regulation and cellular energy.
What the MTHFR gene variant does. When you carry a C677T or A1298C variant, your MTHFR enzyme activity is reduced. C677T homozygous carriers can see up to 70% lower activity. A1298C typically reduces activity by around 40%. Compound heterozygous carriers, one copy of each, often show intermediate reductions. This means standard folic acid supplements may deliver little usable folate regardless of dose.
Why 5-MTHF is the right choice for MTHFR. 5-MTHF (L-methylfolate) is already in its active form. It enters the methylation cycle without passing through the MTHFR enzyme step that the gene variant impairs. This is the core reason clinicians increasingly recommend 5-MTHF over folic acid for anyone with a known MTHFR variant, and why METHL never uses synthetic folic acid.
Methylcobalamin B12 for MTHFR. B12 works alongside folate in the methylation cycle. The active form is methylcobalamin, not the synthetic cyanocobalamin found in most multivitamins. Methylcobalamin pairs directly with 5-MTHF to support homocysteine remethylation and SAMe production. METHL uses methylcobalamin in both the capsule multivitamin and the liquid B-complex drops.
Do you need an MTHFR test before taking methylated vitamins? No. Because 5-MTHF and methylcobalamin are pre-activated forms, they are bioavailable and beneficial regardless of your genotype. People who have not been tested also benefit from skipping the conversion bottleneck. Testing can be useful for understanding your genetic picture but it is not a prerequisite for choosing a better form of folate.
The MTHFR supplement FAQ.
What supplements should I take for MTHFR? +
For MTHFR, the most important thing is the form of folate and B12. Look for 5-MTHF (L-methylfolate) instead of folic acid, and methylcobalamin instead of cyanocobalamin. METHL provides both in a clean, vegan formula. The Methylated Multivitamin covers your complete daily foundation. The Liquid B-Complex adds a concentrated, fast-absorbing dose of active Bs. The Bundle gives you both at the best value.
What is the MTHFR gene mutation? +
MTHFR is a gene that encodes the enzyme methylenetetrahydrofolate reductase. This enzyme converts dietary folate and folic acid into 5-MTHF, the active folate your methylation cycle uses. Gene variants like C677T and A1298C reduce enzyme activity, which can limit how much usable folate reaches your cells even when you supplement regularly with standard folic acid.
Do I need an MTHFR test before supplementing with methylated vitamins? +
No. 5-MTHF and methylcobalamin are active forms that are beneficial regardless of your genotype. They bypass the MTHFR conversion step entirely, so they work whether or not you carry a variant. An MTHFR test can give you useful information about your genetic picture, but it is not required before choosing a better form of folate. Many people start methylated supplements before testing and notice the difference.
Why do methylated forms matter for MTHFR? +
When you carry an MTHFR variant, the enzyme that converts folic acid to usable folate operates at reduced capacity. Synthetic folic acid can accumulate unmetabolized while your cells get less of what they actually need. Methylated forms, 5-MTHF and methylcobalamin, skip that conversion step entirely. They enter the methylation cycle directly, which is why they are the clinically preferred choice for MTHFR carriers and more bioavailable for everyone else.
What is the difference between MTHFR C677T and A1298C? +
C677T is the thermolabile variant. Homozygous carriers (two copies, genotype TT) may have MTHFR enzyme activity reduced by up to 70%. Heterozygous carriers (one copy, CT) see around a 35% reduction. A1298C affects a regulatory region of the enzyme. Homozygous CC carriers can see activity reduced by around 40%. Compound heterozygous individuals (one C677T and one A1298C) often show larger combined reductions. Both variants are bypassed by 5-MTHF supplementation since the active folate does not require MTHFR conversion.
Can I take METHL without knowing my MTHFR status? +
Yes. Active forms like 5-MTHF and methylcobalamin are bioavailable for everyone, not only MTHFR carriers. If anything, the pre-activated forms are a smarter default since roughly 40-60% of people have some reduction in MTHFR activity without knowing it. You get the active nutrients either way.
How long until I feel a difference on methylated supplements? +
Most people notice steadier energy and clearer mood within 30 days of consistent daily use. The timeline varies by individual, starting folate status and which variant (if any) you carry. Consistency matters more than timing. Take them daily with a meal and give it at least a month before evaluating.
Is METHL third-party tested? +
Yes. Every METHL batch is independently tested for purity and potency. The formulas are vegan, non-GMO, made in the USA, and contain no synthetic folic acid, fillers or binders.
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Plus notes on MTHFR, methylation and feeling like yourself again.
