Gary Brecka / 10X / Thorne vs METHL Methylated Multivitamin

If you are comparing the Gary Brecka methylated multivitamin (10X Health’s 10X Optimize) against Thorne’s Methyl-Guard and METHL, the short answer is that all three use active, body-ready folate. The real differences are how complete each formula is, what else is inside, what each brand verifies on its label, and price. This guide lines them up honestly using each brand’s own published product information so you can choose what fits your routine.

METHL is a whole-food, fully methylated daily multivitamin. If you would rather start from the shelf, you can browse the full range of methylated multivitamins & B vitamins and come back to the comparison below.

Who is Gary Brecka and what does 10X Health sell?

Gary Brecka is a human biologist and the co-founder of the 10X Health System (the company was co-founded with Grant Cardone). 10X Health built its brand around genetic testing (it markets a Methylation Genetic Test and a Precision Genetic Test) and a line of supplements meant to pair with those results.

Their daily multivitamin is called 10X Optimize. According to the 10X Optimize product page, it is described as “a methylated multivitamin” and is “formulated with bioavailable forms like 5 MTHF (folate), benfotiamine (B1), pyridoxine (B6) and specialized forms of other vitamins and minerals.” The same page lists additions like NAC and alpha lipoic acid, and prices it at $44.00 for a one-time purchase or $39.60 on subscription (shipping every two months). One thing worth noting: the product page states 5-MTHF for folate, but it lists pyridoxine for B6 rather than the activated P5P form, and it does not publish a B12 form, a third-party testing claim, or a country of manufacture on that page. So if those details matter to you, you would need to confirm them directly with 10X.

What does Thorne offer for methylation?

Thorne is a practitioner-favored brand, and its most relevant product here is Methyl-Guard, a targeted methylation supplement rather than a full multivitamin. Per Thorne’s Methyl-Guard product page and its Supplement Facts panel, each serving provides Folate as L-5-MTHF (2 mg DFE), Vitamin B12 as Methylcobalamin (1.2 mg), Vitamin B6 as Pyridoxal 5′-Phosphate (P5P, 20.4 mg), and Betaine Anhydrous (TMG, 1.8 g). The page lists it as 180 capsules at $56, and positions the product to “support methylation for healthy heart, blood vessels, brain, and bones.”

Thorne markets an NSF-certified supplement line at the brand level. Because Methyl-Guard is a focused methylation formula and not a broad multivitamin, it is a great fit if you specifically want methylation support on top of a separate multi, but it will not cover the full spectrum of daily vitamins and minerals on its own. The betaine (trimethylglycine) in Methyl-Guard is also worth understanding: it is a methyl donor that supports homocysteine metabolism, which is why Thorne frames the product around heart and cognitive support rather than general daily nutrition. If your goal is broad coverage (vitamins A through K, key minerals, and methylated B vitamins in one place), a focused methylation supplement is only part of the equation.

How does METHL compare?

METHL is built as a complete daily multivitamin that is fully methylated from the ground up. It uses 5-MTHF folate, methylcobalamin B12, and P5P B6, the three active B forms together, with no synthetic folic acid. It also adds fermented organic greens, is made in the USA, is third-party tested, and is vegan and non-GMO. The standalone METHL methylated multivitamin is $51.99, and there is a METHL multivitamin + liquid B-complex bundle at $96.99 if you want extra B support layered on top. Every order is backed by a 60-day guarantee.

In plain terms: 10X Optimize is a methylated multivitamin with a genetic-test ecosystem around it; Thorne Methyl-Guard is a focused methylation supplement with fully active B forms; and METHL aims to be a single complete methylated multi with fermented greens, all three active B forms, and transparent label claims in one bottle.

The fermented organic greens are a real point of difference. Neither competitor states a greens blend on the pages we reviewed, so METHL is doing something the others are not: pairing the activated B vitamins your body uses for methylation with whole-food plant compounds in the same daily dose. For a lot of people that means one bottle instead of a multivitamin, a separate greens powder, and a separate methylation supplement. That is usually simpler to stick with and easier on the wallet over a month.

Gary Brecka / 10X vs Thorne vs METHL: side-by-side

Every cell below reflects what each brand publishes on its own product page. Where a brand does not state something on that page, it is marked “not stated” rather than guessed.

What should you actually look for in a methylated multivitamin?

Whether you go with Gary Brecka’s 10X Optimize, Thorne, METHL, or anyone else, the same handful of label details separate a thoughtful formula from a marketing story:

• Active folate, not folic acid. Look for 5-MTHF or L-5-MTHF on the label. This matters most if you carry an MTHFR variant, and our MTHFR guide explains why.
• All three active B forms. The strongest methylation formulas pair active folate with methylcobalamin (B12) and P5P (B6), not just one of the three.
• Complete vs targeted. Decide whether you want one complete daily multivitamin or a focused methylation add-on alongside a separate multi.
• Transparency. A good brand publishes its forms, testing, and origin so you are not guessing. Where a page leaves those blank, ask before you assume.
• Price for what you get. Compare cost against how much each product actually covers. A complete multi and a single-purpose supplement are not the same thing.

If you want a deeper buyer’s walkthrough of the whole category, our best methylated multivitamin guide ranks what to prioritize and why.

How to choose the right fit for you

Pick based on what you are trying to do, not on whose name is on the bottle:

• You want one complete, fully methylated daily multi. The METHL methylated multivitamin covers all three active B forms plus fermented greens in a single $51.99 bottle, third-party tested and made in the USA.
• You want maximum methylation support. The METHL multivitamin + liquid B-complex bundle ($96.99) layers extra B vitamins on top of the daily multi, a clean alternative to buying a multi and a separate methylation supplement like Methyl-Guard.
• You like the genetic-test-first approach. 10X Health’s model is built around testing first, then matching supplements; that ecosystem is the draw of 10X Optimize.
• You only need targeted methylation help. Thorne Methyl-Guard is a solid focused option if you already take a multivitamin and just want active B forms plus betaine.

Frequently asked questions

Does Gary Brecka sell a methylated multivitamin?

Yes. 10X Health, co-founded by Gary Brecka, sells 10X Optimize, which its product page describes as a methylated multivitamin formulated with 5-MTHF folate. The same page prices it at $44.00 one-time or $39.60 on subscription.

Is METHL a good alternative to Thorne Methyl-Guard?

They serve different needs. Thorne Methyl-Guard is a targeted methylation supplement (folate, B12, B6 and betaine) rather than a full multivitamin. METHL is a complete daily multivitamin that is fully methylated, so if you want one product instead of a multi plus a methylation add-on, METHL covers more in a single bottle.

Do all three use the same form of folate?

All three publish an active folate form: METHL uses 5-MTHF, 10X Optimize states 5-MTHF, and Thorne Methyl-Guard states L-5-MTHF. The bigger differences show up in B12 and B6 forms, what else is in the formula, testing transparency, and price.

Which one is best for someone with an MTHFR variant?

Any product using active 5-MTHF (instead of synthetic folic acid) is a reasonable starting point for people who may convert folic acid poorly. METHL pairs 5-MTHF with methylcobalamin and P5P so all three B forms are already active. Read our MTHFR guide for the full picture, and talk to your clinician about your specific situation.

Why does METHL cost more than 10X Optimize?

Each brand prices differently for what it includes. METHL’s $51.99 multivitamin is a complete daily formula with all three active B forms, fermented organic greens, third-party testing, made-in-USA manufacturing, and a 60-day guarantee. Compare total coverage, not just the sticker price.

The bottom line

Gary Brecka’s 10X Optimize, Thorne Methyl-Guard, and METHL all use quality active folate, so none of them are a bad choice. The right pick comes down to whether you want a complete methylated daily multivitamin, a targeted methylation supplement, or a genetic-test-led system. If a single, fully methylated, third-party-tested multivitamin with fermented greens and a 60-day guarantee is what you are after, start with the METHL methylated multivitamin or browse the full range of methylated multivitamins & B vitamins.