Methylated B-complex drops in a clean USP vegetable-glycerin base. Active methylcobalamin and 5-MTHF, built for MTHFR. No alcohol, no oil.
Add METHL Methylated Multivitamin +$51.99Pair the drops with the daily capsule · complete MTHFR-aware stack
Clean methylated B-complex in a USP vegetable-glycerin base. No alcohol, no oil, no synthetic preservatives. Every dose delivers active coenzyme forms, including methylcobalamin (active B12) and L-5-MTHF, plus a Trimethylglycine (TMG) methyl-donor cofactor.
An estimated 40 to 60% of people carry MTHFR gene variants (C677T, A1298C) that reduce the conversion of synthetic folic acid into usable methylfolate. METHL bypasses the conversion: active forms only, the methyl donors your body uses directly.
Free US shipping, most orders out within one business day. Subscriptions ship every 30 days, pause or cancel anytime.
60-day money-back guarantee. Not satisfied? Return within 60 days for a full refund, no questions asked.
"Water-soluble B vitamins do not need an oil or alcohol carrier. A clean vegetable-glycerin base delivers the active, methylated forms directly, which matters most for people with MTHFR variants who cannot rely on synthetic folic acid."
Premium liquid B-complex products usually lean on one of two compromises. Alcohol tinctures use ethanol as a preservative, but ethanol downregulates the intestinal thiamine transporter (THTR-1) and acetaldehyde degrades B6. Oil-based liposomal carriers were engineered for fat-soluble compounds, so wrapping water-soluble B vitamins in a phospholipid shell adds a barrier with no meaningful benefit.
METHL uses USP vegetable glycerin and purified water, the same clean carrier in practitioner-grade supplements from Thorne, Pure Encapsulations and Designs for Health. Plant-derived, self-preserving, naturally sweet without sugar.
Methylated B vitamins, a methyl-donor cofactor, and a vegetable-glycerin base, all in their most usable forms.
L-5-MTHF methylfolate, methylcobalamin B12, P5P (B6) and R5P (B2), the coenzyme forms your body activates for energy, mood and the methylation cycle, with no conversion step.
Betaine (TMG) is a methyl-donor cofactor that works alongside active folate and B12 to support the methylation cycle.
USP vegetable glycerin and purified water. Self-preserving and naturally sweet, with no alcohol and no oil.
L-5-MTHF, methylcobalamin, P5P and R5P. The coenzyme forms your body uses directly, with no conversion.
A clean vegetable-glycerin base. No ethanol to block thiamine, no oil barrier on water-soluble B's.
Plant-derived, gluten free, non-GMO and soy free. Naturally sweet without any added sugar.
Trimethylglycine supports the methylation cycle, working alongside active folate and methylcobalamin.
Active methylfolate and methylcobalamin bypass the folic-acid conversion that MTHFR variants disrupt.
2 mL under the tongue or in water. Easy to dose, fast to take, and gentle on the stomach.
Shake well, then take 2 mL under the tongue or in water. 30 servings per bottle.
Methylated B vitamins your cells use on contact, whatever your genes, in a clean glycerin base.
Energy, nervous-system and methylation support from B's your body can finally use.
Nine active B vitamins and methyl donors, each mapped to the food it comes from. Tap a nutrient to see what it does.
| Amount per serving | Amount | % DV |
|---|---|---|
| Vitamin B1 Thiamine HCl | 2 mg | 167% |
| Vitamin B2 Riboflavin-5-Phosphate | 2 mg | 154% |
| Vitamin B3 Niacinamide, non-flush | 20 mg | 125% |
| Vitamin B5 Calcium Pantothenate | 10 mg | 200% |
| Vitamin B6 Pyridoxine HCl + P5P | 3 mg | 176% |
| Vitamin B7 Biotin | 300 mcg | 1,000% |
| Vitamin B9 L-5-Methyltetrahydrofolate (5-MTHF) | 500 mcg | 125% |
| Vitamin B12 Methylcobalamin | 500 mcg | 20,833% |
| TMG Trimethylglycine (Betaine), methyl-donor cofactor | 20 mg | † |
| What matters | Alcohol tincture | Oil carrier | Folic-acid pill | METHL Liquid B |
|---|---|---|---|---|
| Active methylfolate (5-MTHF) | Sometimes | Sometimes | ✕ | ✓ |
| Methylcobalamin B12 | Varies | Varies | ✕ | ✓ |
| No alcohol | ✕ | ✓ | ✓ | ✓ |
| No oil barrier on water-soluble B's | ✓ | ✕ | ✓ | ✓ |
| MTHFR-ready, active forms | Varies | Varies | ✕ | ✓ |
| Clean vegetable-glycerin base | ✕ | ✕ | N/A | ✓ |
| Taste | Harsh, ethanol burn | Oily | No taste | Naturally sweet |
We partner with top-tier pharmacies that source the finest raw ingredients from around the world.
Every ingredient meets the highest industry standards for purity, potency and bioavailability.
Our formulations are crafted with pharmacies that have a long-standing reputation for excellence.
We source globally to ensure our drops contain the best, most effective nutrients available.
“Absolutely the best vitamins I have ever taken. These vitamins are absolutely the best.”
Absolutely the best vitamins I have ever taken.
These vitamins are absolutely the best.
"I optimized everything and still felt off. Twenty years chasing performance, triathlete, marathon runner, martial artist, and I still couldn't feel the difference. A genetic test explained why: an MTHFR variant meant my body couldn't use standard vitamins. So I built the active forms I needed, including a liquid B that skips the alcohol and the oil entirely."
We're confident you'll love it. If you're not completely satisfied, return it within 60 days for a full refund. No questions asked.
Take 2 droppers daily to experience the difference.
Not satisfied? Reach out for return instructions.
Return it and we'll process your refund promptly.
Methylated B vitamins are already in their active, body-ready form. Many liquid B's use synthetic precursors like folic acid that your body must convert. METHL skips that step, delivering L-5-MTHF, methylcobalamin, P5P and R5P, the forms your cells can use immediately.
Ethanol in alcohol tinctures downregulates the intestinal thiamine transporter (THTR-1) and degrades B6. Oil carriers were built for fat-soluble compounds, so they add a barrier with no benefit for water-soluble B vitamins. USP vegetable glycerin is the clean carrier used by practitioner brands like Thorne and Pure Encapsulations. It is plant-derived, self-preserving, and naturally sweet without sugar.
Yes. Active, methylated forms are bioavailable for everyone, whether or not you carry a variant. An estimated 40 to 60% of people carry C677T or A1298C, but you get the body-ready nutrients either way.
Shake well, then take 2 full droppers (2 mL) daily. Mix into water or juice, or take directly under the tongue. There are 30 servings in each 2 fl oz bottle.
Methylcobalamin is the bioavailable form of B12 your cells use directly, with no conversion step, unlike synthetic cyanocobalamin. It supports energy metabolism, nervous-system function and the methylation cycle, alongside active folate and a TMG methyl-donor cofactor.
Subscribe and save 20% ($36.00, about $1.20 a day). Your bottle ships every 30 days and you can pause, skip or cancel anytime.
Plus the occasional note on methylation, MTHFR and feeling like yourself again.
