The Methylated Multivitamin Born From an MTHFR Gene Mutation
Built by an athlete who couldn’t absorb his own vitamins. Guided by doctors. Formulated with methylfolate, methylated B12, and active-form nutrients for real results.
THE FOUNDER
20 Years Optimizing the Human Body. Then He Discovered His MTHFR Gene Mutation.
Chris Santos spent his entire life in pursuit of human performance — as a triathlete, marathon runner, martial artist, and personal trainer who led a program of 75+ trainers by the age of 29.
He founded Dr Refresh, the highest-rated med spa in West Hollywood, and became the only non-medical Key Opinion Leader in the history of InMode, a billion-dollar global medical device company, lecturing internationally on advanced wellness technology.
He had the diet, the training, the discipline. He took his vitamins every single day. And he never felt a difference. A genetic test would later reveal why — Chris carries the MTHFR gene mutation, meaning his body couldn’t convert standard vitamins into their active, methylated forms.
From Athlete to Methylated Vitamin Innovator
How a personal discovery of the MTHFR gene mutation led to creating the best methylated multivitamin on the market.
A Life of Performance
Decades of elite training — triathlons, marathons, Thai boxing, Brazilian jiu-jitsu. By 29, Chris led 75+ trainers, founded the highest-rated med spa in West Hollywood, and became the only non-medical Key Opinion Leader in InMode’s history.
The MTHFR Gene Mutation
A genetic test revealed Chris carries the MTHFR gene mutation — a variant affecting up to 40% of the population. His body couldn’t convert standard folic acid into methylfolate, or cyanocobalamin into methylated B12. Every supplement he’d taken for years was passing straight through him. Then in 2023, he lost his brother to ALS — deepening his mission to help people take control of their health.
METHL Is Born
Years of research with physicians and compounding pharmacists led to METHL — a methylated multivitamin with active-form nutrients including 5-MTHF (methylfolate), methylcobalamin (methylated B12), a potent immunity blend, and fermented organic greens. Plant-based, pharmacy-grade, made in the USA, third-party tested, vegan, and non-GMO.
Why Choose a Methylated Multivitamin Over Standard Vitamins
THE PEOPLE BEHIND METHL
Formulated by Experts in Methylation and Metabolic Health
FOUNDER & CEO
Chris Santos
Lifelong athlete. Former triathlete, marathon runner, Thai boxer, and Brazilian jiu-jitsu practitioner who led a team of 75+ personal trainers by age 29.
Founder of Dr Refresh, the highest-rated med spa in West Hollywood. The only non-medical Key Opinion Leader in the history of InMode, a billion-dollar global medical device company — lecturing internationally on wellness and aesthetic technology.
After discovering he carries the MTHFR gene mutation, Chris spent years working with doctors and compounding pharmacies to create what didn’t exist on the shelf: a clean, methylated multivitamin with methylfolate and methylated B12 his body could actually use. He personally formulates every METHL product and takes it daily.
MEDICAL ADVISER — METHYLFOLATE PROTOCOL SPECIALIST
Dr. Julius Balogh, MD, MHA
Double board-certified physician specializing in proactive health, metabolic optimization, and longevity medicine.
With firsthand experience in hormone replacement therapy and deep clinical expertise in how the body absorbs and utilizes essential nutrients, Dr. Balogh ensures every METHL formulation meets the highest standards of safety and efficacy.
His passion for preventative health and evidence-based supplementation brings the medical rigor that separates METHL from everything else on the shelf.
OUR MISSION
No One Should Take a Supplement Their Body Can’t Use.
Most vitamins are built for the shelf, not for your body. We exist to change that.
We deliver high-potency, methylated, plant-based supplements free from fillers, binders, and synthetic ingredients — formulated for real absorption by real humans. Our Methylated Multivitamin features 5-MTHF (methylfolate), methylcobalamin (active B12), an immunity blend, and fermented organic greens. Our Liquid Liposomal B Complex delivers methylated B vitamins in liposomal form for maximum bioavailability.
Whether you carry the MTHFR gene mutation or you simply want methylated vitamins that actually work, METHL was made for you.
LOOKING FORWARD
The Future of Vitamins Isn’t One-Size-Fits-All.
We believe the supplement industry is broken — built on outdated science, cheap ingredients, and the assumption that every body works the same way. It doesn’t.
Our vision is to set a new standard for what a methylated multivitamin should be: clean, pharmacy-grade, clinically effective, and designed around how your body actually works. No more wondering if your methylfolate supplement is doing anything. No more synthetic fillers disguised as health.
METHL is just the beginning. We’re building a complete line of methylation-optimized supplements — each product formulated for real absorption, real impact, and real humans. Every bottle we make is designed to end the doubt.
Pharmacy-Grade Standards for Every Methylated B12 and Methylfolate Ingredient
Premium Ingredient Sourcing
We partner with top-tier pharmacies that source the finest raw ingredients from around the world.
3rd Party Tested
Every ingredient meets the highest industry standards for purity, potency, and bioavailability.
Trusted, Proven Partners
Our formulations are crafted in collaboration with pharmacies that have a long-standing reputation for excellence and safety.
Global Sourcing
We source globally to ensure our vitamins contain the best, most effective nutrients available.
Frequently Asked Questions About Methylated Vitamins and MTHFR
What is the MTHFR gene mutation?
MTHFR is a common genetic variation that affects up to 40% of the population. It impairs your body’s ability to convert folic acid and certain B vitamins into their active, usable forms. If you have this variant, standard multivitamins may pass through your body without being absorbed. METHL uses pre-activated, methylated forms that bypass this conversion entirely.
How is METHL different from other multivitamins?
Most multivitamins use cheap, synthetic forms of nutrients that require your body to convert them before use. METHL uses methylated, active-form ingredients — like methylfolate instead of folic acid and methylcobalamin instead of cyanocobalamin — so your body can use them immediately. We’re also free from fillers, binders, and artificial additives, with every batch third-party tested.
Do I need MTHFR to benefit from METHL?
No. While METHL was specifically designed with MTHFR carriers in mind, methylated vitamins are more bioavailable for everyone. Even without the mutation, your body absorbs active-form nutrients more efficiently than synthetic alternatives.
Where is METHL manufactured?
All METHL products are formulated and manufactured in the USA in partnership with licensed compounding pharmacies. We source premium raw ingredients globally and every batch undergoes third-party testing for purity, potency, and bioavailability.
What are the key ingredients?
METHL formulas feature methylfolate (5-MTHF), methylcobalamin (active B12), organic turmeric, and fermented greens. Every ingredient is vegan, gluten-free, non-GMO, and serves a specific functional purpose. No filler ingredients, ever.
Is METHL safe to take with other supplements?
METHL is formulated with clean, bioavailable ingredients that are generally well-tolerated. As with any supplement, we recommend consulting your healthcare provider before combining with other supplements or medications.
What are methylated vitamins and why do they matter?
Methylated vitamins are nutrients already converted into their active, bioavailable form. Unlike standard synthetic vitamins (like folic acid or cyanocobalamin), they don’t require your body to perform a conversion step before use. This is critical for the estimated 40% of people with MTHFR gene mutations who can’t efficiently make that conversion. Key examples include methylfolate (active folate), methylcobalamin (active B12), and pyridoxal-5-phosphate (active B6). Learn more about methylated vitamins →
Are methylated vitamins better than regular vitamins?
For many people, yes. Methylated vitamins are already in their active form, meaning your body can absorb and use them immediately without conversion. This is especially important for the 40% of the population with MTHFR gene mutations, but even people without the variant benefit from higher bioavailability. Studies show methylfolate is more effective at raising folate levels than folic acid. Similarly, methylcobalamin (methylated B12) is better retained by the body than cyanocobalamin. See how methylated B vitamins compare →
What are the benefits of METHL’s methylated multivitamin?
The METHL Methylated Multivitamin ($51.99) provides nutrients in their most bioavailable form for maximum absorption. It features 5-MTHF (methylfolate), methylcobalamin (methylated B12), a potent immunity blend, and fermented organic greens. Benefits include better folate and B12 utilization, support for healthy methylation cycles, improved energy metabolism, and no risk of unmetabolized folic acid buildup. Pharmacy-grade, plant-based, vegan, non-GMO, and made in the USA.
Ready for a Methylfolate Supplement Designed for How Your Body Works?
Join thousands choosing methylated vitamins with methylfolate and active B12 — designed for the 40% with MTHFR and everyone who wants vitamins that work.